Internal Job Title: Senior Scientist II

Position Location: Cambridge, MA, onsite

We are currently seeking individuals with strong expertise in functional genomics and iPSC-based disease modeling. The ideal candidate will have substantial experience in genomic screening and complex cell models. You will be responsible for developing and optimizing cell-based assays specifically for high-throughput functional genomic screening, with the goal of identifying targets and accelerating therapeutic development.

Your responsibilities include, but are not limited to:

• Develop and optimize cell-based biological assays for high-throughput genomic screening.
• Candidates should have extensive experience in cell culture, particularly with iPSCs and advanced complex cell models such as organoids and primary cells, as well as strong proficiencies in functional genomics.
• Experience with human blood-brain barrier (BBB) models using iPSC-derived cells would be a plus.
• Stay up-to-date with the latest advancements in genomic science and screening methodologies to provide actionable insights for process improvement.
• Contribute to the publication of research findings and present at scientific conferences, keeping the scientific community abreast of cutting-edge developments.

Minimum Requirements:

• PhD with 0-2 years in biology (or relevant field), with applicable related experience.
• Proficient with mammalian cell culture and experience with iPS derived cell models/ physiologically relevant in vitro disease models. Expertise with complex models, such as poly-culture or organoids.
• Demonstrated familiarity with both genomics perturbagens, including strengths and liabilities of each class (siRNA, CRISPR, cDNA).
• Strong problem-solving skills and attention to detail, with good troubleshooting and resolving technical challenges in automated assay development.
• Strong organizational and project management skills, with the ability to work in a fast-paced, collaborative environment.

The salary for this position is expected to range between $93,800 and $174,200 per year. 

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. 

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.